Over the years, Bernie found that low dose naltrexone (LDN) had a much wider use than for what became known as HIV/AIDS. In his private practice, he began to see people with a variety of cancers as well as those with a host of different autoimmune diseases, many of whom appeared to benefit from the use of LDN. Find patient medical information for Naltrexone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Abstract. The purpose of this paper is to review low-dose naltrexone (LDN) for use in clinical practice. The known or theoretical mechanism of action of LDN, clinical research findings in relation to various medical conditions including pain, autoimmune conditions, cancer, and mood disorders will be discussed. The serendipitous discovery of low-dose naltrexone (LDN) spurred a revolution in the background of medicine. Studies reveal it may help people with complex autoimmune diseases, chronic pain, inflammation, cancer, infections, and autism. By Dr. Mercola. It is not often that I advocate the use of prescription drugs, but low-dose naltrexone (LDN) is one of those rare exceptions that may hold the promise of helping millions of people with cancer and autoimmune disease. Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. Many people don’t know what low dose naltrexone is, or the benefits it offers. However, this substance has been proven beneficial against a number of diseases, including cancer, as well as autoimmune disorders. Low-dose naltrexone has the potential to reduce the terrible human loss now taking place throughout the globe. It is a drug that could prevent millions of children from becoming AIDS orphans. It is a drug that could be a powerful ally in the war against cancer. Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as Crohn's disease and multiple sclerosis, but evidence for recommending such use is lacking. Aside from the brain benefits of low dose naltrexone, there are many more common uses. One of the most popular is as a cancer therapy. One animal study found low-dose naltrexone could be coupled with chemo and radiotherapy as a unique treatment for cancer [8].